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Accutane is a medicine that remodels the treatment of acne. Accutane belongs to the family of drug called retinoids, which are similar to vitamin A. Accutane, like other retinoids, works by changing the DNA transcription. These affect by minimizing the size and output of sebaceous glands. It also makes the cells that are sloughed off into the sebaceous glands less sticky, and therefore fewer chances to form blackheads and whiteheads. It also minimizes the number of bacteria in the sebaceous gland and on the skin surface.

Accutane is generally indicated for nodular, pustular acne that has not responded to full courses of several oral antibiotics. The trend in Accutane prescribing for acne has been towards using it earlier in the course of the disease process, especially if there is significant scarring. While Accutane is used primarily for severe acne, it has also been used for other disorders such as lupus, psoriasis and lichen planus, with varying degrees of success.

Several dosing regimens are used, but the most common drug regimen involves starting with a low dose, then increasing the dose after several weeks. The period of the treatment course varies but generally lasts from 16 to 20 weeks. Some people notice that their acne gets worse after starting Accutane drug therapy. The number of acne lesions usually does not increase in number; rather the lesions may become redder or more painful. This is normal, lasts only a short period of time, and is not a reason to stop using Accutane.

The side effects of Accutane have been a controversial topic and the most noticeable, serious, side effect is its teratogenicity. This means that Accutane causes birth defects if women take it while they are on pregnant state. The birth defects Accutane causes include facial, central nervous system, cardiac, and thymus gland abnormalities. After Accutane treatment has been completed for one month, a woman can get pregnant without worrying about birth defects. Accutane does not affect fertility of a woman, or make it difficult to get pregnant. Women who are taking Accutane should use two forms of birth control starting a month before treatment and continuing one month after the said treatment.